Biography
Dr Resham is a Principal Research Officer, Principal Investigator at the Clinical Research Unit at Khoo Teck Puat Hospital. Upon receiving PhD at National University of Singapore (NUS) in 2012, Dr Resham undertook his post-doctoral training at the Institute of Molecular and Cell Biology (IMCB), A*STAR with Professor Sydney Brenner (Nobel Laureate) and Professor B. Venkatesh (Comparative Genomic Lab). He researched on identifying rare genetic variants related to a metabolic disturbance in the local population. He then joined as a Post-doctoral Fellow at MRC Genome Damage and Stability Centre in the United Kingdom. Dr Resham joined KTPH as Clinical Scientist in 2015.
Dr Resham clinical research team actively seeks to understand the etiology of cardio-renal diseases in Asian populations using multi-omics approaches. These include (1) novel omics biomarker discovery; (2) using genetics to infer causality and discover new druggable targets (Mendelian Randomization); (3) identification of genetic variants associated with ageing and metabolic diseases using large cohort studies. Since 2020, in collaboration with clinicians, the group has pioneered clinical research using customized gene panels and long-chain PCR assay (MonoGenic
Hypertension (MGH) Study) to screen for several forms of monogenic hypertension locally. Recently, the group has embarked on new studies, including epigenetic and blood profiling to understand mechanisms linking successful diet-induced weight loss, diabetes remission and hypertension.
Dr Resham enjoys teaching and mentoring graduates, undergraduates and diploma students. Since 2019, he lectures on Functional Ageing module at NUS. Currently, he is an Adjunt Assistant Professor at Cardiovascular and Metabolic Disorders at Duke-NUS Medical School and Associate Editor of Cardiovascular Diabetology.
Selected Publications
- Liu JJ, Liu S, Wang J, Pek SLT, Lee J, Gurung RL, Ang K, Shao YM, Tavintharan S, Tang WE, Sum CF, Lim SC. Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients with Type 2 Diabetes. Diabetes Care. 2023 Feb 1;46(2):408-415. (Impact Factor=16.2)
- Wang J, Liu JJ, Gurung RL et al. Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with type 2 diabetes. Diabetologia 2022 Jun 28 (IF= 8.2)
- Gurung RL et al. Genetic risk score for plasma uric acid levels is associated with early rapid kidney function decline in type 2 diabetes. J Clin Endocrinol Metab. 2022 Apr 1 (IF= 5.8)
- Liu JJ, Liu S, Wang J, Lee J, Tang JI, Gurung RL et al. Risk of Incident Heart Failure in Individuals With Early-Onset Type 2 Diabetes. J Clin Endocrinol Metab. 2022 Jan 1;107(1). (IF=5.8)
- Gurung RL et al. Association of leukocyte telomere length with chronic kidney disease in East Asians with type 2 diabetes: a Mendelian randomization study. Clin Kidney J. 2021 Mar 26;14(11):2371-2376 (IF=4.6)
- GurungRL et al. Association of Genetic Variants for Plasma LRG1 With Rapid Decline in Kidney Function in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. 2021 Jul 13;106(8):2384-2394 (IF=5.8)
- Gurung RL et al. Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss. Obesity (Silver Spring). 2020 Dec;28(12):2424-2430. (IF=6.9)
- Ooi DSQ, Dorajoo R, Gurung RL, Dehghan R, Lim YY, Ho CWL, Tay V, Karuppiah V, Loke KY, Lim SC, Liu JJ, Sng AA, Lee YS. Association of leukocyte telomere length with obesity-related traits in Asian children with early-onset obesity. Pediatr Obes. 2021 Jan 26. (IF=3.9)
- Gurung RL et al. Ethnic disparities in relationship of obesity indices and telomere length in Asians with type 2 diabetes. J Diabetes. 2018 Oct 3.(IF=4.5)
- Gurung RL et al. Association of haptoglobin phenotype with incident acute myocardial infarction in Chinese patients with type 2 diabetes. Cardiovasc Diabetol. 2019 May 30;18(1):65.(IF= 9.3)
- Dorajoo R*, Chang X*, Gurung RL* et al. Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nat Commun. 2019 Jun 6;10(1):2491. (IF=16.6) (*Joint first co-author)
- Gurung RL et al. Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians. Sci Rep. 2018 Mar 23;8(1):5109 (IF=4.6)
- Liu JJ, GurungRL et al. Association of young onset age and genetic risk of beta cell dysfunction with glycaemic progression in individuals with Type 2 diabetes. Diabetes Meta.2021 Nov;47 (6):101238 (IF=7.2)
- GurungRL et al. Short leukocyte length predicts albuminuria progression in individuals with type 2 diabetes. Kidney Int Rep.2017 Dec 16;3(3):592-601 (IF=6.0)
- Liu JJ, Liu S, GurungRL et al. Urine tricarboxylic acid cycle metabolites predicts progressive chronic kidney disease in type 2 diabetes. J Clin Endocrinol Meab. 2018 Dec 1 (IF=5.8)
- Chang X, GurungRL et al. Low frequent variants associated with leukocyte telomere length in the Singapore Chinese population. Commun Bio. 2021 May 3 (Impact factor:5.9)
Conference and Media Hightlights
- Short leukocyte telomere length is associated with increased risk for albuminuria progression in type 2 diabetes in Asians - Media Centre | EASD (2017)
- Berita Harian ("Kajian KTPH buka jalan bagi rawatan penyakit kencing manis lebih tepat", 15 November 2022
- 联合早报 ("糖尿病患者分类型 护理治疗更精准", 28 February 2023
Notable Research Awards & Grants from Past 5 Years
Name of Awards & Grants
| Year Obtained |
---|
DYNAMO II: Diabetes StudY in Nephropathy And other Microvascular cOmplications II (MOH-001327-02), NMRC (Co-PI)
| 2023 |
Diet-induced weight loss impact on biological ageing and benefits in patients with early T2D - A pilot study (PI)
| 2023
|
STAR22206: Integrating clinical and genomic information for treatment of monogenic Hypertension (PI)
| 2022
|
STAR22109: Biomarker study of blood pressure response to diet induced weight loss in type 2 diabetes (PI)
| 2022
|
AHF Program grant: Application of genomic information to identify novel biomarkers, causal factors, and therapeutic targets for chronic kidney disease in type 2 diabetes (PI)
| 2022
|
AHF Program grant: Identification of novel genetic variants for angiogenic factors and Mendelian randomisation analysis to determine its causal role with diabetic kidney disease (PI)
| 2020
|
STAR18115: Assessing causality: Is hyperuricemia renal toxic in type 2 diabetes? A pilot study (PI)
| 2018
|
STAR17109: Association of Haptoglobin genotype with end stage renal disease, cardiovascular disease and all-cause mortality in type 2 diabetes patients with chronic kidney disease in multi-ethnic Asian population (PI)
| 2017
|
AHEG1622: Association of telomere length with progression of chronic kidney disease in patients with type 2 diabetes in Asian population (PI)
| 2016
|
Collaborations
- National University of Singapore
- National University Hospital
- Changi General Hospital
- Genome Institute of Singapore, A*STAR
- Institute of Molecular and Cell Biology, A*STAR
Link to Google scholar
https://scholar.google.co.uk/citations?user=112XAmMAAAAJ&hl=en