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Clinical Research


Research Grants

Grant Awardee Funder Amount
2017
Clinician Scientist Award (CSA)A/Prof Lim Su ChiNMRC$1,555,670
RIE2020 Centre Grant (CG) – Common and Complex Chronic Conditions – Focusing on Cohorts and Clinical Epidemiology Mrs Chew Kwee TiangNMRC$1,370,699
RIE2020 Centre Grant (CG) – Singapore Imaging Eye Network (SIENA)Mrs Chew Kwee TiangNMRC$294,073
Open Fund – Large Collaborative Grant (LCG)A/Prof Lim Su Chi (KTPH)NMRC$5,688,350.75
2018
Individual Research Grant (IRG)A/Prof Lim Su ChiNMRC$ 1,444,448.36
Research Training Fellowship (RTF)Dr Benjamin Lam Chih ChiangNMRC$500,000
Clinician Scientist Fellowship (CSF)Dr Benjamin Lam Chih ChiangNHG/LKC$114,000 + 0.19FTE
2019
Research Training Fellowship (RTF)Dr Low Kiat Mun SerenaNMRC$500,000
Clinician Scientist Fellowship (CSF)Dr Low Kiat Mun SerenaNHG/LKC$90,000 + 0.15FTE
Masters in Clinical InvestigationDr Benjamin YipMOH$5,000 + $25,000

Industry Alignment Fund - Pre-Positioning

(IAF-PP)

Dr Kenny SzeBMRC$341,604
Traditional Chinese Medicine Research Grant (TCMRG)Dr James Tan Chung HuiMOH$233,023
2020
Clinician Scientist / Clinician Investigator Salary Support Programme (CISSP)Dr Allen LiuNMRC$65,000
COVID-19 MedTech Innovation GrantDr Angeline SeahNHG$18,400

Industry Alignment Fund - Pre-Positioning

(IAF-PP)

Dr Leong Chuo RenBMRC$53,940

Grants Awardees

Department: Acute & Emergency Care

No. Principal Investigator Project Title

1.

Dr Desmond Mao

Alcohol-Related Frequent Attenders to an Emergency Department - A Qualitative Study

National Paramedic Termination of Resuscitation 2 Study

Department: Clinical Research Unit

No. Principal Investigator Project Title

1.

Dr Pek Li Ting Sharon

Evaluation of novel cardiovascular biomarker, Histidine-rich glycoprotein (HRG), in patients with Familial Hypercholesterolemia

2.

Ms Clara Chan

Longitudinal Change in Urinary Haptoglobin and Renal Outcomes in Type 2 Diabetic Patients

3.

Ms Michelle Lin Xueqin

Study on oxidative stress in Singapore Familial Hypercholesterolemia population in relation to effects of cardiovascular events

4.

Dr Ang Su Fen

Evaluation of ethnic-specific PAX4 R192H genetic variation as a potential early marker for cognitive impairment in Chinese patients with Type 2 diabetes.

5.

Dr Low Kiat Mun Serena

A study on the association between nocturnal hypoxemia and chronic kidney disease in Type 2 diabetes

6.

Ms Kwan Tsz Kiu

The association of dietary acid load on metabolic acidosis complications among the community-dwelling T2DM Singaporean elderly with CKD. A validation study in SMART2D

7.

Mr Lee Wei Lun Janus

Association of mitochondrial Haplogroup N9a to diabetic kidney Disease in Singapore Chinese with type 2 diabetes

8.

Ms Yiamunaa M

Relationship of Physical Activity and Diet with Ageing in local T2D population – a pilot study

Department: General Medicine

No. Principal Investigator Project Title

1.

Dr Selene Teoh Tse Yen

Comparison of Standard versus High Dose Urokinase for Dysfunctional Tunneled Dialysis Catheters in Haemodialysis Patients: A Randomized Controlled Trial

Department: General Surgery

No. Principal Investigator Project Title

1.

Dr Lee Yao Zong

Opioid sparing strategy post emergency laparotomy - Comparison of Pre-Peritoneal Catheter (PPC) vs Transversus Abdominis Plane (TAP) block: a Randomized Controlled Trial

Department: Orthopaedic Surgery

No. Principal Investigator Project Title

1.

Dr Antony Xavier Rex Premchand

Finite Element and Biomechanical Analysis of PFNA Blade Position in the Osteoporotic Femur

Department: Psychological Medicine

No. Principal Investigator Project Title

1.

Dr Lim Wei Shyan

Online Multi-Component Intervention for Alleviating Depression and Enhancing Well-Being

Department: Renal Centre

No. Principal Investigator Project Title

1.

Dr Chen Shune

Handheld US guided Cannulation of Hemodialysis Arteriovenous Access by Renal Nurses

2.

Ms Si Chanjuan

The Effectiveness of ChloraShield TM Chlorhexidine Gluconate Antimicrobial Dressing for the Prevention of Non-tunneled Temporary Dialysis Catheter Related Infections among Haemodialysis Patients in a South-east Asian Cohort

Department: Acute & Emergency Care

Principal Investigator:
Dr Huang Po Yu

Project Title:
Study of synovial lactate levels as a marker of septic arthritis

Principal Investigator:
Dr Desmond Mao

Project Title:
National Paramedic Termination of Resuscitation 2 Study

Department: Cardiology

Principal Investigator:
Dr Justin Tang

Project Title:
Whole exome sequencing in a family with monogenic hypertension

Department: Clinical Research Unit

Principal Investigator:
Dr Moh Mei Chung

Project Title:
Association between resolution of hepatic steatosis and restoration of glycemic control in patients who underwent metabolic surgery

Principal Investigator:
Dr Resham Gurung

Project Title:
Assessing the correlation of telomere length in leukocytes and adipocytes in Bariatric surgery patients - A pilot study

Principal Investigator:
Dr Sharon Pek

Project Title:
Evaluation of polygenic risk score for clinically-diagnosed Familial Hypercholesterolemia in a Singapore cohort

Principal Investigator:
Dr Zhang Xiao / Dr Keven Ang

Project Title:
Fruit and vegetable intake assessed by food frequency questionnaire and serum carotenoids: A validation study in FAMILY GENES

Principal Investigator:
Mr Chan Zit Liang Eric

Project Title:
Association of Orosomucoid and Diabetic Peripheral Neuropathy

Principal Investigator:
Ms Clara Chan

Project Title:
Association of Mitochondrial Haplogroups N9a and M8a with severity of Type 2 Diabetes complications in a Chinese population

Principal Investigator:
Ms Lai Wanxin / Ms Bhuvaneswari Pandian

Project Title:
Transcriptomic analysis of inflammatory mediators in visceral adipose tissue as predictors of refractory type 2 diabetes following metabolic surgery

Principal Investigator:
Ms Michelle Lin Xueqin

Project Title:
Circulating PCSK9 levels and neutralizing antibody in response to proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors therapy: promising tools to explain lipid-reduction variability

Principal Investigator:
Ms Yiamunaa M

Project Title:
Association between global methylation status and telomere length dynamics in Chinese Type 2 diabetes patients - a 3 years prospective study

Department: Orthopaedic Surgery

Principal Investigator:
Dr Timothy Teo Wei Wen

Project Title:
Is higher insertional torque of interference screw associated with higher pullout strength of reconstructed graft in Primary Anterior Cruciate Ligament reconstruction surgery? - A Biomechanical Study

Principal Investigator:
Dr Toon Dong Hao

Project Title:
Articular contact area and pressure of the humeral head in functional range of motion of the shoulder: A Cadaveric Study

Department: Rehabilitation Services

Principal Investigator:
Ms Giang Thuy Anh

Project Title:
TPilot Study: The Effects of Horticultural Therapy on Engagement and Mood of Inpatient Older Adults in an Acute Care Hospital

Department: Renal Centre

Principal Investigator:
Sister Tan Si Hui

Project Title:
Tegaderm™ chlorhexidine gluconate-gel dressing for the prevention of exit site infection in patient receiving peritoneal dialysis

Science - Translational & Applied Research (STAR) I & II are grants designed to support clinical and translational research that answer specific, targeted research questions; or to perform pilot or feasibility studies.

STAR I supports small start-up exploratory studies that may provide preliminary findings for larger research proposals.

STAR II is a follow-on grant offered to successfully completed STAR I projects. It is designed to encourage continuing translation of research into patient care.

For FY2020, 7 projects were awarded. Our heartfelt congratulations to the following awardees:

STAR I Awardees

No. Principal Investigator Department Project Title

1.

Dr Ang Kue-Loong Keven

Clinical Research Unit

A FAMILY based approach to study GENetic and Environmental factorS in diabetic nephorpathy (FAMILY GENES)

2.

Dr Resham Lal Gurung

Clinical Research Unit

Genetic analysis for monogenic hypertension in a clinical setting among hypertensive patients in the local population - A pilot study

3.

Dr Serena Low

Clinical Research Unit

Navigating the paradigm of testosterone deficiency in men with Type 2 diabetes - interplay of sex hormones, body composition and diabetic complications 

4.

Ms Tan Si Hua Clara

Clinical Research Unit

Young-onset diabetes - Lifestyle, Omics and Outcome (YOLO) cohort - a pilot study

STAR II Awardees

No. Principal Investigator Department Project Title

1.

Dr Angela Moh Mei Chung

Clinical Research Unit

Establishing the First-in-Singapore Yishun Health Campus (NHG) Registry for Monogenic Obesity

2.

Dr Liu Jianjun

Clinical Research Unit

Tubulopathy and advrse renal outcomes in patients with Type 2 diabetes - a prospective study in KTPH Smart2D cohort

3.

A/Prof Tavintharan Subramaniam

Clinical Research Unit, Diabetes Centre

The ULCER (Understanding Limb Complications and Event Rates) Study


Researcher Investigator Scientist Enabler (RISE) is a grant scheme that provides funding for a portion of the clinician’s salary commensurate with his/her time spent in research. This funded time will allow the clinician to focus on sharpening their research capabilities.

Our heartfelt congratulations to the following FY2020 awardees:

No. Principal Investigator Department

1.

Dr Desmond Mao Renhao

Acute & Emergency Care

2.

Dr Kumari Neelam

Opthalmology and Visual Sciences

 

Grant Type: STAR I Awardees

Principal Investigator:
Dr Sharon Pek

Department:
Clinical Research Unit

Project Title:
Prospective observational evaluation of glycaemic variability, risk factors and co-morbidities in patients with treatment-induced neuropathy of diabetes

Principal Investigator:
Dr Angela Moh

Department:
Clinical Research Unit

Project Title:
Prospective evaluation of the association of non-alcoholic fatty liver disease with progression of diabetic kidney disease - a substudy of 2017/0056

Principal Investigator:
Dr Serena Low

Department:
Clinical Research Unit

Project Title:
Navigating the paradigm of diabetes mellitus in the elderly – unravelling the interplay between hyperglycaemia, body composition and frailty

Principal Investigator:
Dr Grace Tan

Department:
General Medicine

Project Title:
Automated Lung Ultrasound (LUS) Image Assessment Using Artificial Intelligence To Identify Fluid Overload In Dialysis Patients

Principal Investigator:
Ms Clara Tan

Department:
Clinical Research Unit

Project Title:
Beyond diabetes and back: understanding the clinical and molecular spectrum of HNFβ (MODY5) associated disease among people with structural renal anomalies

Principal Investigator:
Dr Neelam Kumari

Department:
Ophthalmology & Visual Sciences

Project Title:
Nutrigenomics in pathological myopia with and without myopic Macular Degeneration

Grant Type: STAR II Awardees

Principal Investigator:
A/Prof Edwin Seet Chuen Ping

Department:
Anaesthesia

Project Title:
Multicentre Randomized Controlled Trial for the Prevention of Postoperative Adverse Outcomes in Surgical Patients with Untreated Obstructive Sleep Apnoea (POSA-II Trial)

Principal Investigator:
Dr Ang Su Fen

Department:
Clinical Research Unit

Project Title:
Precision medicine for early-onset diabetes: developing a risk prediction and stratification model

Principal Investigator:
Dr Serena Low

Department:
Clinical Research Unit

Project Title:
Economic burden of progressive Type 2 Diabetes and its complications in Singapore – direct, indirect and intangible costs

Principal Investigator:
Dr Doreen Tan

Department:
Pharmacy

Project Title:
iRight4Me Acute Coronary Syndrome

AHS Research Commemorative Book

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