Saw Swee Hock School of Public Health (SSHSPH)
With our comprehensive lab facility and excellent research teams, we have had multiple fruitful collaborations with international leading scientists and institutions.
- Prospectively follow up individuals with diabetes recruited from our Diabetes Centre (collaboration with SSHSPH and NUS)
- A multi-institutional collaboration with SSHSPH involved Tan Tock Seng Hospital, Genome Institute of Singapore, B.R.A.H.M.S Biotechnology centre (Germany) and Singapore General Hospital. It studied the association between pathway-related candidate genes with “intermediate phenotype” and diabetic nephropathy using customised microarray of 1,536 SNPS.
Genome Institute of Singapore (GIS)
Our Infection Control team has ongoing collaborations with GIS which includes environmental surveillance of Methicillin-resistant Staphylococcus aureus (MRSA) and genomic exploration of the nasal microbiome in S. aureus carrier and non-carriers.
Our common interest in the genetics of diabetic nephropathy also led to a fruitful collaboration with GIS.
Future collaborations include genetics of healthy aging.
NHG Institutions (TTSH, NHGPs)
Our research team specialising in diabetes and urology is intrigued by the genetics implications in diabetes nephropathy. With this special interest in mind, we have teamed up with Tan Tock Seng Hospital (TTSH).
We also worked with NUS, NHG Polyclinics and TTSH to study how to better manage diabetes in patients under the care of specialist centres.
National University Health System (NUHS)
A collaboration was also made with Biopolis and NUS to study the molecular epidemiology of nephropathy secondary to type 2 diabetes.
Dr Subramaniam Tavintharan is working with NUS on the mechanisms of simvastatin-induced hepotoxicity to study hepatic gene expression profiles to explain the pathogensis of hepatopathy.
Dr Subramniam Tavintharan is also working closely with Saw Swee Hock School of Public Health, NUS, on untargeted metabolomics to understand how certain metabolite signatures can distiguish patients of different glucose tolerance.
We have also had continuous collaboration with the Department of Biochemistry in NUS to study the genome wide transcriptomic study on HepG2 cells treated – with NUS Dept of Biochemistry
Another collaboration with the Department of Biochemistry, NUS involves miRNA profiling of subjects with and without metabolic disorders.
We collaborated with the School of Chemical and Life Science, Nanyang Polytechnic to identify novel urinary biomarkers in non-albuminuric diabetic nephropathy subjects.
Singhealth Services (SGH, SERI)
Dr Lim Su Chi has had a multi-institutional collaboration with SGH, SERI and NUS to study the metabolic syndrome and microangiopathies in Asians.
Another collaboration sees Dr Lim Ling Choo working with NUS, NUH and SGH on the study Detection of RET/PTC expression and its role as a molecular and prognostic marker in our local patients with papillary thyroid carcinoma.
Singapore Institute of Clinical Science, A*STAR
Our bariatric surgery and adipocytes biology research attracted strong interest from leading international scientists from SICS, like Prof Sir Peter Gluckman, Prof Judith Swain and Dr Michael Meaney.
We will be collaborating with SICS on a translational medicine approach to identify genomic and epigenomic causes of Type 2 Diabetes Mellitus.
We are also part of the Singapore Consortium of Cohort Studies (SCCS) which is a national effort to develop a large multi-ethnic population-based cohort study that would facilitate research into the complex gene-environment interactions in diseases such as diabetes, cardiovascular diseases and cancers. Specifically, we are involved in examining the genetic and environmental factors that are important in the development of diabetic complications in diabetic patients.