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CLINICAL RESEARCH
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Based on global statistics, Familial Hypercholesterolemia (FH) affects approximately
20,000 patients in Singapore but more than 90% are unaware of this condition
and remain undiagnosed! Early diagnosis can allow affected individuals and their
family members to start treatment early and ultimately reduce the risk of getting early
heart attack.
FH leads to early heart disease, the #1 killer in the world
Men with FH have 50% risk of having heart disease by age of 50
Women with FH have 30% risk of having heart disease by age of 60

Based on global statistics, Familial Hypercholesterolemia (FH) affects approximately 20,000 patients in Singapore but more than 90% are unaware of this condition and remain undiagnosed! Early diagnosis can allow affected individuals and theirfamily members to start treatment early and ultimately reduce the risk of getting early heart attack.

FH leads to early heart disease, the #1 killer in the world

Men with FH have 50% risk of having heart disease by age of 50.

Women with FH have 30% risk of having heart disease by age of 60

You may have FH if you have any of the following symptoms/signs
1. High blood cholesterol
 Total cholesterol >7.5mmol/L or 290mg/dl
 LDL-cholesterol >4.9 mmol/L or 189mg/dl
2. Family history of
 a. High cholesterol or
 b. Early heart attack or
 c. Cholesterol deposit around eyes and under skin
3. Mutation test (clinical research) 

You may have FH if you have any of the following symptoms/signs

1. High blood cholesterol 

2. Family history of 

A. High cholesterol or B. Early heart attack or C. Cholesterol deposits around eyes or under skin

3. Positive Mutation


Where can I check my cholesterol levels?

You can get your cholesterol levels checked at any public or private clinics. If you suspect you may have one of the above conditions, discuss with your doctor.

Family screening & early treatment

If you have high cholesterol and test positive for mutation, higher dosage of medication may be required. Lifestyle changes such as healthy diet, exercise and medication can help to reduce the risk of heart attack. Early diagnosis and treatment are available. Take action now and seek medical advice.

 

If you do a mutation test and discover the mutations, your doctor will share the findings with you and advise your immediate family members to come for testing. Patients with FH mutation have a 50% chance of passing to their children. Early detection will allow you and your affected family members to start medication early and reduce the risk of premature heart attack. 

In collaboration with Singapore Heart Foundation, the FHCARE team from KTPH has set up a booth on National Heart Week/World Heart Day 2018 on 29 September 2018 to help raise FH awareness to the public. This event is celebrated annually by Singapore Heart Foundation (SHF) provides a platform to motivate fellow Singaporeans to lead a positive and active lifestyle.

Publications
Pek SLT, Sanjaya Dissanayake, Fong JCW, Lin MX, Chan EZL, Tang JIS, Lee CW, Ong HY, Sum CF, Lim SC,Tavintharan S. Spectrum of mutations in index patients with familial hypercholesterolemia in Singapore: Single Center Study. Atherosclerosis 2018; 269:106-116
Grants
STAR18202 Prospective observational study of potential genetic and biochemical predictors to response to cholesterol-lowering therapy in patients with Familial Hypercholesterolemia
STAR16104 Combination of molecular genetic testing and clinical diagnosis for familial hypercholesterolemia (FH) / Autosomal Dominant Hypercholesterolemia (ADH) AHEG1503 Combination of molecular genetic testing and clinical diagnosis for familial hypercholesterolaemia and familial combined hypercholesterolaemia: Pilot study

Publications

Pek SLT, Sanjaya Dissanayake, Fong JCW, Lin MX, Chan EZL, Tang JIS, Lee CW, Ong HY, Sum CF, Lim SC,Tavintharan S. Spectrum of mutations in index patients with familial hypercholesterolaemia in Singapore: Single Center Study. Atherosclerosis 2018; 269:106-116

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Atherosclerosis 2018; 277:234-255.

Grants

STAR18202 Prospective observational study of potential genetic and biochemical predictors to response to cholesterol-lowering therapy in patients with Familial Hypercholesterolaemia

STAR16104 Combination of molecular genetic testing and clinical diagnosis for familial hypercholesterolaemia (FH) / Autosomal Dominant Hypercholesterolaemia (ADH)

AHEG1503 Combination of molecular genetic testing and clinical diagnosis for familial hypercholesterolaemia and familial combined hypercholesterolaemia: Pilot study

Singapore Heart Foundation 2018 - 2021: Improving awareness and identification of Familial Hypercholesterolaemia in Singapore among healthcare professionals and patients

FHCARE Research study

Enrollment:Till 31st March 2020

Cost:

No charge for cholesterol test. Volunteers will be reimbursed travel expenses.

What the study involves:

  • Up to 2 visits
  • Screening for cholesterol: Total cholesterol >7.5mmol/lLDL-cholesterol >4.4mmol/l
  • Family history taking

Genetic testing is performed on a research basis and the results will not be recorded in the clinical notes.

1) If you are a patient who is interested to participate in our study

Please contact:

FHCARE team

Hotline: 6602 2346

Email: cholesterol.info@ktph.com.sg

By sending us your personal information, you are deemed to have consented for our study team to contact and invite you to participate in our clinical trials/research. Collection, use and disclosure of your personal data shall be in accordance with our privacy policy which is available at http://www.ktph.com.sg/pdpa.

2) If you are a physician looking to refer your patient(s)

Please contact:

FHCARE team

Hotline: 6602 2346

Email: cholesterol.info@ktph.com.sg

Please ensure that patient consent for collection, use and disclosure of his/her information has been obtained and documented, according to PDPA requirement. Our study team will contact you/patient and the information collected will be kept confidential.

This study is approved by NHG Domain Specific Review Board (DSRB 2015/00249) and the study team, follows all DSRB guidelines to protect personal health information. This registry is supported and funded by Alexandra health Ptd Ltd Science Translational and Applied Research (STAR1 and 2) grants.