You are here: Home > Healthcare Professional > Clinical Research > MODY Registry Study
Adjust font size:
  • What is MODY?
  • MODY Registry
  • Do I have MODY?
  • Contact Us
MODY stands for Maturity-Onset Diabetes of the Young. It is a type of diabetes that is caused by a single gene abnormality (mutation) and is also known as monogenic diabetes. MODY can often be misdiagnosed as the common Type 1 or Type 2 diabetes as they share similar features. Determining the gene mutation in MODY is important to confirm the diagnosis.
Mutation in more than 20 genes have been shown to cause MODY. The most common ones include HNF4A, GCK and HNF1A (MODY-1,-2 and -3) as well as KCNJ11 and ABCC8 (can cause diabetes as young as 1 year old or less, i.e. neonatal diabetes). These genes directly affect the ability of the insulin-producing cells in the pancreas to sense, produce and release insulin, which is required to control sugar levels in our body.

The KTPH-NHG MODY Registry is set up as part of our research study to identify individuals with MODY and to provide a genetic diagnosis for this group of individuals. A genetic diagnosis of MODY may aid doctors in providing the best treatment for these individuals (e.g. switching from insulin to tablets).

News Feature

Patient with rare diabetes tracked with new registry (The Sunday Times, 15/10/2017)

Related publication
A preliminary study to evaluate the strategy of combining clinical criteria and next generation sequencing (NGS) for the identification of monogenic diabetes among multi-ethnic Asians.
Related publication
A preliminary study to evaluate the strategy of combining clinical criteria and next generation sequencing (NGS) for the identification of monogenic diabetes among multi-ethnic Asians.

Find out more about our research study on MODY at our registry page now !


Targeting primarily the population-catchment of NHG- Yishun campus, the KTPH-NHG MODY registry is set up with the following primary aims:

  • To identify individuals with MODY and to perform genetic testing for these group of individuals.
  • To facilitate optimization of treatment by their care-provider for individuals with confirmed genetic diagnoses (e.g. switching from insulin to oral anti-diabetic medications like sulphonylureas).
  • To provide MODY-related counselling to affected individuals and their family members.
  • To provide a platform for gathering longitudinal information to better understand and treat monogenic diabetes.

Your participation will help us understand the genetic basis of monogenic diabetes, and also answer questions such as the number of people who are affected in our local population, the type of treatment that is best for each different genetic type, and other medical problems that might arise due to the presence of such gene mutations. These information will help doctors understand the genetic basis of the disease and offer suitable treatment to the patients.

You may have MODY if you have any of the following features:

  • Diabetes diagnosed when you were less than 35 years old. We strongly recommend people with diabetes-onset below 1 year old to receive genetic testing.
  • Type 2 Diabetes (T2D) but not overweight
  • Longstanding T2D that is well controlled with diet alone
  • Strong family history of diabetes (more than 2 generations)

Interested to find out more and participate in our study?

If you think you have MODY and would like to participate in our study, kindly email the following details to

  • Salutation (Mr/Ms/Mdm)
  • Full name
  • Contact number
  • Email address

By sending us the above information, you are deemed to have consented for our study team to contact and invite you to participate in our clinical trials/research. Collection, use and disclosure of your personal data shall be in accordance with our privacy policy which is available at

Are you a physician looking to refer your patient(s)?

More information on our study inclusion & exclusion criteria can be found here.

If you would like to refer your patient, please email the following details to

Patient Details
  • Salutation (Mr/Ms/Mdm)
  • Full name
  • Contact number
  • Email Address
Physician Details
  • Physician name
  • MCR number
  • Clinic/Hospital
  • Address
  • Contact number
  • Email address

Please ensure that patient consent for the collection, use and disclosure of his/her information has been obtained and documented, according to PDPA requirement. Our study team will contact you/patient via the provided contact details. All personal information provided will be kept confidential.

Other enquiries?

Please contact us at



Participation in the KTPH-NHG Monogenic Diabetes Registry is voluntary and there is no charge to participate. Genetic testing for MODY is performed on a research basis and will be provided at no cost for individuals who are eligible and have given consent for the study.

This study is approved by the NHG Domain Specific Review Board (DSRB 2017/00276) and the research team follows all DSRB guidelines to protect personal health information.