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CLINICAL RESEARCH
Obesity - Metabolism & Intervention Cohort Study (OMICS)

 

Obesity is a complex multifaceted disease arising from interactions of biological, behavioural and environmental factors, and contributes to many comorbid conditions e.g. Type 2 diabetes (T2DM). Bariatric Surgery (also known as Gastrointestinal Surgery, or Bariatric and Metabolic Surgery) is highly effective in inducing weight loss among morbidly obese individuals thereby ameliorating adverse metabolic consequences.

The OMICS project is co-initiated by Dr Anton Cheng (Deputy Director of Weight Management Programme at our Health For Life Centre) and Dr Lim Su Chi (Clinical Director, Clinical Research Unit) to provide resources for conducting multidisciplinary research in fields such as epidemiology, genetics, metabolomics, lifestyle and nutrition to elucidate obesity pathophysiology among multi-ethnic Asians in Singapore.

Constituting the core of OMICS is a prospective-cohort founded since 2007. To date, it has ~400 severely obese (mean BMI~40 kg/m2) individuals who underwent bariatric surgery. About one-third of them has T2DM, whom we have performed pre- and post-bariatric surgery multiple time-point OGTT. Additionally, we have established a rich bio-repository of bio-banked blood and urine samples, cryopreserved human primary adipocytes (both subcutaneous and visceral), skeletal myocytes and longitudinal clinical data collected from the research participants.

The goals of the OMICS project are:
  • 1. To understand the best practice for candidate-selection to derive benefit from bariatric surgery
  • 2. To unveil the mechanisms elicited by bariatric surgery so as to facilitate the development of powerful non-invasive interventions for improving obesity and/or T2DM
  • 3. To identify biomarkers to better risk-stratify obesity/T2DM patients i.e. personalized medicine


Publications

Pek SL, Sum CF, Lin MX, Cheng AK, Wong MT, Lim SC, Tavintharan S. Circulating and visceral adipose miR-100 is down-regulated in patients with obesity and Type 2 diabetes. Mol Cell Endocrinol. 2016;427:112-23.

Toy WC, Liu JJ, Cheng AKS, Tan CSH, Lau DP, Wong MDS, Tavintharan S, Sum CF, Lim SC. Adiponectin gene polymorphisms and type 2 diabetes among Singaporean Chinese adults. J Diabetes Metab. 2011;2(8): 1000152.
Kiong KL, Ganesh R, Cheng AKS, Lekshiminarayanan R, Lim SC.  Early improvement in type 2 diabetes mellitus post Roux-en-Y gastric bypass in Asian patients. Singapore Med J 2010; 51(12) 937.

Ngiam KY, Lee WJ, Lee YC, Cheng A. Efficacy of metabolic surgery on HbA1c decrease in type 2 diabetes mellitus patients with BMI <35 kg/m2--a review.  Obes Surg. 2014 Jan; 24(1):148-58.


Conference Abstracts

Moh MC, Lian M, Ang SF, Wong MDS, Zhang X, Lim SC. Whole exome sequencing on a large cohort of severely-obese individuals to investigate pancreatic β-cell function related protein-coding variants potentially protective against type 2 diabetes in the metabolically healthy non-diabetic group. AFES 2017, Yangon, Myanmar.

Moh MC, Lim SC, Lim BK, Tavintharan S, Sum CF, Cheng AKS. Evaluation on the early effects of bariatric surgery on the outcome of type 2 diabetes in obese patients. ICO 2014, 12th International Congress on Obesity, Malaysia, Kuala Lumpur.

Moh MC, Cheng AKS, Pek SLT, Lim BK, Wong MDS, Lim SC. Alteration of the plasma amino acid profile predicts glucose tolerance after gastro-intestinal metabolic surgery in obese patients with type 2 diabetes. Singapore Health and Biomedical Congress 2015, Singapore.

Wong MDS, Moh MC, Cheng AKS, Tan LT, Lim BK, Pek SLT, Sum CF, Tavintharan S, Lim SC. Elevation of plasma long-chain acylcarnitines in obese patients with non-remission of type 2 diabetes after bariatric surgery. Singapore Health and Biomedical Congress 2015, Singapore.

Toy WC, Liu JJ, Cheng AKS, Wong MDS, Sylvia, Tan CSH, Sum CF, Lim SC. TNF-α induce fractalkine expression via activation of NF-kB in human adipocytes. Singapore Health and Biomedical Congress 2012, Singapore.

Toy WC, Cheng AKS, Tan TJ, Lau DP, Rajmohan L, Tan CSH, Wong MDS, Tavintharan S, Sum CF, Lim SC. The effect of PPARï?§ Rosiglitazone on the gene expression profile of subcutaneous vs visceral adipocytes. Alexandra Health Research Forum 2011, Singapore.

Lau DP, Toy WC, Cheng AKS, Tan CSH, Wong MDS, Narayanan R, Sum CF, Tavintharan S, Lim SC. Differential gene expression of inflammatory cytokines and receptors between human visceral and subcutaneous adipose tissue. Alexandra Health Research Forum 2011, Singapore.

Toy WC, Tan JJ, Lau DP, Tan CSH, Wong MDS, Tavintharan S, Sum CF, Lim SC, Cheng AKS. The miRNA profiling on the effect of Rosiglitazone on subcutaneous vs visceral adipocytes. Asia-Pacific Metabolic and Bariatric Surgery Society. 21st Oct 2010. Singapore. 


Conference Papers

Lap adj Gastric Band for morbid Obesity Results at 5 years. Free paper. Aaron Poh, A Cheng. APMBSS Congress Singapore Oct 2010

Early improvement in Type 2 DM post RYGB in Asian patients. G Xu, A Cheng. APMBSS Congress Singapore Oct 2010

Laparoscopic Adjustable gastric Banding our 5 years experience in AH/KTPH. Ganesh R, A Cheng. ELSA Congress Singapore August 2011

Biliopanceatic diversion as a revision bariatric procedure our case series. Ganesh R, A Cheng. ELSA Congress Singapore August 2011

Single incision sleeve gastrectomy. Ganesh R, A Cheng. ELSA Congress Singapore August 2011

Single incision sleeve gastrectomy video presentation.  HS Ho, WD Lau, Desmond Ooi, A Cheng. ELSA Congress Singapore August 2011

Laparoscopic Biliopancreatic Diversion, video presentation. Lau WD, Cheng A. ELSA Congress Singapore August 2011

Lengthening of BP limb post BPD due to severe malnutrition. Video presentation. Tan CC, Cheng A. ELSA Congress Singapore August 2011

Endoscopic stenting of GJ anastomotic leak after RYGB. Desmond Ooi, Ho HS, Lau WD, AKS Cheng. ELSA Congress Singapore August 2011

Reasons for loss to follow up in our Bariatric Surgical Center. Lucy Kong, Ganesh R, A Cheng. ELSA Congress Singapore August 2011

Laparoscopic Adjustable Gastric Banding 10 years experience, IFSO congress New Delhi, Oct 2012
Glycaemic Control after Gastric Bypass Surgery in Morbidly Obese Patients with Diabetes Mellitus: An Asian Experience, IFSO congress New Delhi, Oct 2012


Media Reports

Khoo Teck Puat Hospital studying effectiveness of bariatric surgery

More opt for drastic weight-loss surgery

Stomach Surgery solves her health woes